J Respir Med Lung Dis | Volume 2, Issue 3 | Research Article | Open Access
Maher Mubarak AlQuaimi1, James B Fink2 and Arzu Ari2*
1Department of Respiratory Therapy, Dammam University, Dammam, Saudi Arabia
2Department of Respiratory Therapy, Georgia State University, Atlanta, GA, USA
Introduction: The aim of this study was to evaluate the efficiency of aerosol devices in a simulated adult lung model using different NIV masks.Methods: A ventilator with NIV circuit was attached via face mask to a manikin with a collecting filter at the level of the bronchi attached to a passive test lung. Aerosol devices: (1) Jet Nebulizer (JN); (2) Vibrating Mesh Nebulizer (VMN) and (3) Pressurized metered-dose inhaler (pMDI), were placed between the leak port and mask. NIV with PIP/PEEP of 20/5 cmH2O was used with full face mask, oro-nasal mask, and Performa track mask (Philips, Murrysville, PA). Albuterol sulfate (2.5 mg/3 ml) was nebulized with JN and VMN. Fourpuffs from a pMDI (108 μg/puff) were emitted into a spacer (Aerovent, Monaghan/Trudell) in recommended and reverse orientation (n=3). Drug was eluted from filters and analyzed by UV/Spec at 276 nm. Inhaled mass and percent of nominal/ emitted dose were quantified. Descriptive statistics, Kruskal Wallis analysis of variance, and Mann- Whitney U tests were used for data analysis.Results: During NIV, inhaled mass percent ranged from 13.12% ± 0.72% to 28.83% ± 1.93% across devices. VMN had greater inhaled mass than JN (p=0.0001). Efficiency of pMDI was similar with both orientations (p=0.253). Both Solo and NIVO were more efficient with oro-nasal mask than full face mask (p=0.012 and p=0.037, respectively.)Conclusion: The efficiency of aerosol devices and masks during NIV varied in this simulated adult lung model. The JN was less efficient than either VMN or pMDI with spacer.
Noninvasive positive pressure ventilation; Aerosols; Inhalation devices; Metered dose inhalers; Nebulizers and vaporizers; Vibrating mesh nebulizer
AlQuaimi MM, Fink JB, Ari A. Efficiency of Different Aerosol Devices and Masks during Noninvasive Positive Pressure Ventilation in a Simulated Adult Lung Model. J Respir Med Lung Dis. 2017; 2(3): 1018.