Ann Nutr Food Sci | Volume 4, Issue 1 | Mini Review | Open Access

Recombinant Antimicrobial Peptides - Concepts and Applications

Komal Ghauri¹, Muhammad Afzal Ghauri² and Amer Jamil^3*

¹Biotechnology of Prebiotics and Antimicrobials Lab, National Institute for Biotechnology and Genetic, Pakistan ²Industrial Biotechnology Division, National Institute for Biotechnology and Genetic Engineering, Pakistan ³Department of Biochemistry, University of Agriculture, Pakistan

^*Correspondance to: Amer Jamil 

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Abstract

Antimicrobial Peptides (AMPs) are cationic, amphipathic, which are effective against a number of pathogens and hold a novel place in pharmaceutical field. Mode of action includes the attack on pathogen’s membrane that increases permeability of the membrane resulting in uncontrolled iontransport and finally the membrane is ruptured. The expression systems mainly used are of E. coli and Pichia pastoris. Codon preference is also considered while expressing protein. Some examples of AMPs include Hepcidin, Magainin, ORBK, Fowlicidin, Porcine protegrin-1, AMP-MP1102, Plectasin, NZ17074, Dybowskin-2 CAMA, Enterocin L50, SRCAM 602, OR-7 E-760 and L-1077. Among these Hepcidin, Magainin, Fowlicidin and Porcine protegrin-1 are commercially available. The increasing trend of drug resistant against bacterial pathogens has paved the path for the development of new antibiotic backbones. In the present scenario, PepSAVI-MS pipeline has been developed for bioactive peptides. This platform uses mass spectrometry and statistical approaches to identify bioactive peptides from complicated biological samples. The antimicrobial peptides have a great potential in drug discovery and commercial applications.

Keywords:

AMPs (Antimicrobial Peptides); Mode of action; Applications; History

Citation:

Ghauri K, Ghauri MA, Jamil A. Recombinant Antimicrobial Peptides - Concepts and Applications. Ann Nutr Food Sci. 2020; 4(1): 1045.