Ann Nutr Food Sci | Volume 2, Issue 4 | Review Article | Open Access

Toll-like Receptor 4: Target of Lipotoxicity and Exercise- Induced Anti-inflammatory Effect?

Sihui Ma¹ and Katsuhiko Suzuki^2*

¹Graduate School of Sport Sciences, Waseda University, Japan
²Faculty of Sport Sciences, Waseda University, Japan

^*Correspondance to: Katsuhiko Suzuki 

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Abstract

Toll-Like Receptors (TLRs) are a main target during inflammation and metabolic syndromes as receptors for inflammatory signaling molecules, and are named numerically from 1 to 13 in humans. It is believed that TLR4 plays a key role in exercise training-induced anti-inflammatory effects, whereas new evidence shows that TLR4 is the main receptor in fatty acid-induced inflammation. In this review, we summarized classical theories, and the new discovery in the field of fatty acidinduced inflammation through TLR4. Further, we highlight the anti-inflammation ability of exercise through regulating TLR4 as we try to acquire new clues for the treatment of metabolic diseases, and understand the regulatory effect of exercise.

Citation:

Ma S, Suzuki K. Toll-like Receptor 4: Target of Lipotoxicity and Exercise- Induced Anti-inflammatory Effect? Ann Nutr Food Sci. 2018; 2(4): 1027.