Irene Garcia-Gabay1*, Leslie Chavez-Galan1,3 and Bernhard Ryffel2*
1Department of Pathology and Immunology, University Medical Center, Switzerland
2Experimental and Molecular Immunology and Neurogenetics, University of Orleans, France
3Integrative Immunology Laboratory, National Institute of Respiratory Diseases, Mexico
Acute Respiratory Distress Syndrome (ARDS) is a major medical emergency requesting acute therapeutic intervention. Here we report that Nitric Oxide (NO) gas attenuates ARDS in mice. Using a novel portable NO generator we found that NO at 20 ppm attenuates endotoxin (LPS) induced neutrophil recruitment lung alveolar epithelial damage reduced inflammatory cytokines, neutrophil. Therefore, the data suggest that the use of a portable NO generator may be considered as an interesting therapeutic possibility for patients with severe ARDS.
ARDS; Endotoxin; Nitric oxide; NO portable generator
Garcia-Gabay I, Chavez-Galan L, Ryffel B. Nitric Oxide to Treat ARDS by a Mobile NO Generator. Int J Intern Emerg Med. 2021; 4(1): 1038.