Int J Intern Emerg Med | Volume 1, Issue 1 | Review Article | Open Access
Maria Augusta Roos and Antonio Ponzetto*
Department of Medical Sciences, University of Turin, Italy
*Correspondance to: Antonio Ponzetto
Fulltext PDFPreeclampsia is a leading cause of maternal and fetal/neonatal mortality and morbidity worldwide. The early identification of patients with an increased risk for preeclampsia is therefore one of the most important goals in obstetrics. The availability of highly sensitive and specific physiologic and biochemical markers would allow not only the detection of patients at risk but also permit a close surveillance, an exact diagnosis, timely intervention (e.g. fetal-lung maturation), as well as simplified recruitment for future studies looking at therapeutic medications and additional prospective markers. Today, several markers may offer the potential to be used, most likely in a combinatory analysis, as predictors or diagnostic tools. Microparticles constitute a cellular marker of a pro inflammatory and procoagulant responses in normal pregnancy. In pre-eclamptic situations circulating MP with procoagulant potential may be part of the exacerbation of these responses.
Microparticles; Exosomes; Endothelium; Endothelial-derived; Platelets; Plateletderived; Syncytiotrophoblast-derived; Diseases; Tissue factor; Extracellular matrix; Preeclampsia
Roos MA, Ponzetto A. Microparticles and Pre-eclampsia. Int J Intern Emerg Med. 2018;1(1):1002.