Ann Stem Cells Regen Med | Volume 1, Issue 2 | Mini Review | Open Access

The Effects of Genetic Alteration on Reprogramming of Fibroblasts into Induced Pluripotent Stem Cells

Yanbin Fu^#, Lingjun Zheng^# and Chao Zhang^*

Department of Translational Medical Center for Stem Cell Therapy, Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University, China

^*Correspondance to: Chao Zhang 

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Abstract

Induced Pluripotent Stem Cells (iPSCs) can be generated from somatic cells by ectopic expression of Yamanaka factors (Oct4, Sox2, Klf4 and c-Myc) or combination of other factors. Genetic alteration of fibroblasts exhibits an effect on reprogramming efficiency through multiple signaling pathways, including epigenetic modifications, metabolic shifts, Mesenchymal-To-Epithelial Transition (MET) and cell proliferation. In order to better understand the underlying mechanisms in cell fate determination, in this review we will summarize several genetic alterations involved in the regulation of reprogramming fibroblasts into iPSCs.

Citation:

Fu Y, Zheng L, Zhang C. The Effects of Genetic Alteration on Reprogramming of Fibroblasts into Induced Pluripotent Stem Cells. Annals Stem Cell Regenerat Med. 2018;1(1):1007.