Ann Pharmacol Pharm | Volume 7, Issue 1 | Research Article | Open Access
Norio Ogata* and Michiyo Shimokawa
Taiko Pharmaceutical Co., Ltd., Osaka, Japan
*Correspondance to: Norio OgataFulltext PDF
Chlorine dioxide gas has strong bactericidal and virucidal activities against many microbes, and is frequently used to disinfect microbes. However, its concentration should be controlled accurately in rooms so that it remains effective enough to kill microbes, but is safe for humans. Therefore, it is important to know how much chlorine dioxide gas is delivered from commonly used domestic gasgenerating devices or spray units. The aim of this paper was to measure concentrations of chlorine dioxide gas in room air delivered from a common market-sold gas-generating device (canister) and its aqueous solution delivered by its spray unit. The chlorine dioxide gas concentration in room air was measured after the canister was placed in a room or after the chlorine dioxide aqueous solution was sprayed in a room. Particle diameters and their numbers in room air were also measured after the use of the spray. The chlorine dioxide gas concentration was 0.007 ppmv to 0.026 ppmv (volume ratio) 60 days after placing the canister in the room. The rate of decay constant during 60 days was 5.6 day-1. When the chlorine dioxide aqueous solution was sprayed in a room, the gas concentration was 0.003 ppmv to 0.019 ppmv during 60 min with a rate of decay constant of 12.7 min-1. The concentrations of chlorine dioxide gas were safe to humans present in the room, and were sufficient to effectively inactivate microbes in the room. These results justify the safe and effective use of chlorine dioxide gas-generating devices and spray units to disinfect microbes, such as SARS-CoV-2 and highly pathogenic avian influenza virus, in closed and poorly ventilated areas without evacuating humans.
Chlorine dioxide; Gas; Spray; Aerosol; Disinfection; SARS-CoV-2
Ogata N, Shimokawa M. Concentrations of Chlorine Dioxide Gas in Room Air During the Use of Its Generator and Spray. Ann Pharmacol Pharm. 2022;7(1):1205..