Ann Pharmacol Pharm | Volume 7, Issue 1 | Review Article | Open Access
Department of Pharmacy, Negelle Health Science College, Ethiopia
*Correspondance to: Gudisa BeredaFulltext PDF
The initial part of human body influenced by the virus is the lung epithelial cells and the 1st traipse of viral infection encloses its attaching to angiotensin converting enzyme-2 receivers delineated on the host cells pursued by budding with the cell membrane. Hydroxychloroquine can obviate viral attachment and entry into host cells by injuring glycosylation of angiotensin converting enzyme-2, thus rupturing the interaction between S protein and angiotensin converting enzyme-2. Chloroquine is known to obviate virus infection by escalating endosomal pH required for virus endosome fusion and release of viral deoxyribonucleic acid or ribonucleic into the cytosol. Dexamethasone would confines the generation and injuring outcome of the cytokines, but will also obviate the protective work of T cells and downgrade the capability of B cells to synthesize antibodies. Heparin has been revealed to de-escalate the expression of proinflammatory mediators in human alveolar macrophages damaged by lipopolysaccharide and to de-escalate the NF-κB pathway in alveolar cells.
Medications; Prophylaxis; SARS-CoV-2; NF-κB pathway
Bereda G. Medications Used for SARSCoV- 2 Prophylaxis and Treatment. Ann Pharmacol Pharm. 2022;7(1):1203..