Ann Pharmacol Pharm | Volume 3, Issue 1 | Review Article | Open Access

Release of Tetracycline out of PLLA Foils Functionalized by Adhesive Polyelectrolyte Complexes in the Context of Parodontitis Therapy

Müller M¹,^2*, Hinüber C³, Vehlow D^1,2 and Urban B¹

¹Department of Polyelectrolytes and Dispersions, Leibniz Institute of Polymer Research Dresden, Germany
²Department of Chemistry and Food Chemistry, Technical University Dresden, Germany
³Department of Processing, Leibniz Institute of Polymer Research Dresden, Germany

^*Correspondance to: Müller M 

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Abstract

For the therapy of parodontitis degradable poly(L-lactide) (PLLA) based threads are envisioned, which can be functionalized by relevant antibiotics. In this context first results on the release of tetracycline (TCL) out of PLLA specimens modified by casting and drying adhesive TCL loaded polyelectrolyte complex (PEC) particles are presented. A significant delay of the TCL release was found for the modification based on PEC/TCL in comparison to that based on pure TCL.

Keywords:

Parodontitis; Drug delivery; Poly(L-lactide); Tetracycline; Polyelectrolyte complex

Citation:

Müller M, Hinüber C, Vehlow D, Urban B. Release of Tetracycline out of PLLA Foils Functionalized by Adhesive Polyelectrolyte Complexes in the Context of Parodontitis Therapy. Ann Pharmacol Pharm. 2018; 3(1): 1138.