Ann Pharmacol Pharm | Volume 2, Issue 13 | Research Article | Open Access
Michihisa Tohda*
Division of Medicinal Pharmacology, Institute of Natural Medicine, and Wakan-yaku Theory-Based Integrated
Pharmacology, Graduate School of Innovative Life Science, University of Toyama, Japan
*Correspondance to: Michihisa Tohda
Fulltext PDFThe 5 sites for RNA editing on 5-HT2C receptor are well known. On these sites, adenosine deaminases acting on RNA (ADARs) are involved in the reactions which convert adenine on RNA to inosine resulting that the inosine acts as guanine. Many reports exist about the physiological significance. In this article, novel 4 sites finding in the 3rd intracellular loop site of 5-HT2CR using NG-108-15 cells were reported. There are 3 subtype of ADAR. The type-3 was not expressed in NG108-15cells. Combining with previous report, the type-1 ADAR also seems to be involved in the novel RNA editings. Editing rates of 5 reported sites in 5-HT2C receptors change during neuronal development. Although the functional significance of newly finding 4 sites is still unknown, further studies will be continued in considering the relationship with neuronal development since these sites were found in undifferentiated neuronal cloned cells.
Tohda M. Novel RNA Editing Sites of 5-HT2C Receptor Encoding the Third Intracellular Loop Domain in Undifferentiated NG108-15 Cells. Ann Pharmacol Pharm. 2017; 2(13): 1136.