Ann Pharmacol Pharm | Volume 2, Issue 13 | Case Report | Open Access

Malignant Peritoneal Mesothelioma with Production of G-CSF: Case Report and Review of the Literature

Nobuhisa Matsuhashi1*, Takao Takahashi1, Satoshi Matsui1, Hideharu Tanaka1, Toshiyuki Tanahashi1, Hisashi Imai1, Yoshihiro Tanaka1, Kazuya Yamaguchi1, Kazuhiro Kobayashi2, Natsuko Suzui2, Tatsuhiko Miyazaki2 and Kazuhiro Yoshida1*

1Department of Surgical Oncology, Gifu University School of Medicine, Japan
2Department of Pathology, Gifu University Hospital, Japan

*Correspondance to: Nobuhisa Matsuhashi 

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Abstract


Background: This report presents the first case, to the authors’ knowledge, of tumor resection of a malignant deciduoidperitoneal mesothelioma producing granulocyte-colony stimulating factor (G-CSF). Case
Presentation: A 62-year-old man presented with a huge tumor located bilaterally over his entire abdominal cavity along with signs of fever and abdominal distension. Laboratory findings showed an increased white blood cell count and C-reactive protein level. The patient underwent surgical removal of the tumor along with tissue from the abdominal wall, and histopathological analysis led to a diagnosis of malignant peritoneal mesothelioma of the deciduoid type positive for G-CSF production based on serum level and immunohistochemical findings. Although the patient’s general condition quickly improved after surgery, local recurrence 7 months after the first chemotherapy treatment and 12 months after the first operation resulted in his death from the primary disease.
Conclusion: We report a very rare case of G-CSF-producing malignant peritoneal mesothelioma from the clinical course through to the valuable autopsy results.

Keywords:

Malignant peritoneal mesothelioma; G-CSF

Citation:

Matsuhashi N, Takahashi T, Matsui S, Tanaka H, Tanahashi T, Imai H, et al. Malignant Peritoneal Mesothelioma with Production of G-CSF: Case Report and Review of the Literature. Ann Pharmacol Pharm. 2017; 2(13): 1131.

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