Ann Pharmacol Pharm | Volume 2, Issue 11 | Case Report | Open Access
Bader Alyahya1,2*, Farah Saleh3 and Ryan Chuang3
1King Saud University, Riyadh, Saudi Arabia
2Clinical Pharmacology and Toxicology Program, McGill University, Montreal, Canada
3Departments of Emergency and Internal Medicine, University of Calgary, Canada
*Correspondance to: Bader Alyahya
Fulltext PDFContext: In North America, opioid-related deaths are on the rise. We report a case of pediatric cardiac toxicity likely related to illicit fentanyl ingestion. Case Details: A 14-year-old male ingested half of an unknown illicit pill. Two hours post ingestion, the patient experienced loss of consciousness, hypotension, cyanosis and diaphoresis. Initial labs revealed elevations in lactate and high sensitivity troponin levels. Chest pain was reported 8 hours post hospital arrival. A chest X-ray revealed right-sided aspiration pneumonia. An electrocardiogram showed ST elevation over the anterior leads and T wave inversion over the inferior leads. An echocardiogram demonstrated borderline systolic function. Cardiac inflammation in the RCA and LAD distributions was evident on cardiac magnetic resonance imaging. Comprehensive urine drug screen was positive for fentanyl and its metabolites, cannabinoids, ondansetron, metoclopramide and ranitidine and was negative for xylazine. The management consists of the administration of non-invasive positive-pressure ventilation, naloxone, dopamine, nor epinephrine and ceftriaxone. 24 hours post admission, the patient was weaned off inotropes and discharged home five days post presentation. A repeat cardiac MRI performed 6 months post ingestion was normal.
Conclusion: There appears to be a relation between pediatric illicit fentanyl use and cardiac toxicity that warrants further analysis.
Non-pharmaceutical fentanyl; Illicit; Overdose; Cardiac injury
Alyahya B, Saleh F, Chuang R. A Pediatric Case of Cardiac Toxicity Associated With Illicit Fentanyl Ingestion. Ann Pharmacol Pharm. 2017; 2(11): 1108.