Ann Pharmacol Pharm | Volume 2, Issue 9 | Review Article | Open Access

A Brief Review on Cancer Stem Cells

Satyanarayana Rentala1*, Animisha Mokkapati1, Radhakrishna Nagumantri1, Chinnababu Pydi1, Pavan Kumar Rambatla2, Donthamsetty Nageswara Rao3 and Aruna Lakshmi Komarraju2

1Department of Biotechnology, GITAM Institute of Technology, GITAM University, India
2Department of Biotechnology, GITAM Institute of Science, GITAM University, India
3Department of Biochemistry, GITAM Institute of Medical Sciences and Research, GITAM University, India

*Correspondance to: Satyanarayana Rentala 

Fulltext PDF

Abstract

More than a decade ago, the existence of a rare population with both stem cell-like properties and tumor initiating capability was first identified in acute myeloid leukemia and, subsequently, in several solid tumors. These populations with stem cell-like properties were termed ‘cancer stem cells (CSCs)’, indicating that only a subset of cancer cells were tumorigenic and able to initiate and produce the bulk of tumors, thus also termed ‘tumor initiating cells’. In this mini review on issues such as cancer stem cells markers, integrins, Matrix metallo-proteinases, chemokines and chemokine receptors are described to study the cancer stem cells associated metastasis. In this review article, several mechanisms and signaling pathways of cancer stem cells during self-renewal and differentiation were mentioned.

Keywords:

Cancer stem cells; Matrix metallo-proteinases; Chemokines and integrins

Citation:

Rentala S, Mokkapati A, Nagumantri R, Pydi C, Rambatla PK, Rao DN, et al. A Brief Review on Cancer Stem Cells. Ann Pharmacol Pharm. 2017; 2(9): 1095.

Subscribe to Our Newsletter