Ann Pharmacol Pharm | Volume 2, Issue 9 | Review Article | Open Access
Deval J Modi* and Divyesh H Shastri
K B Institute of Pharmaceutical Education, Kadi Sarva Vishwavidyalaya, India
*Correspondance to: Deval J Modi
Fulltext PDFFluidized Hot-melt granulation is an agglomeration process; granules are obtained by melting binders that are heated to near or above their melting point. FHMG is an innovative technique involving meltable binder to agglomerate fluidized dry powders. Fluidized Hot-melt granulation techniques have received enhancing attention due to the significant advantages compared to the other granulation methods. Fluidized hot melt granulation (FHMG) is recommended as promising technique. FHMG is simple and rapid granulation technique that enables a scientist to manipulate drug release rate depending on the properties and concentration of the meltable binder. It provides a sophisticated robust process for poorly soluble drug of oral dosage form. Proper selection & optimization of formulation, equipment & process related variable in Fluidized hot melt granulation can lead to successful scale up of Fluid-bed processing technology from the small scale to large scale production successfully.
Fluidized hot melt granulation; Fluidized bed granulation; Fluidized bed process; Meltable binder
Modi DJ, Shastri DH. Fluidized Hot Melt Granulation: Promising Technique for Dissolution Enhancement. Ann Pharmacol Pharm. 2017; 2(9): 1093.