Ann Pharmacol Pharm | Volume 2, Issue 7 | Research Article | Open Access
SV Tembhurne1*, More B H2 and D M Sakarkar3
1Department of Pharmacy, AISSMS College of Pharmacy, India
2Department of Pharmacy, Yadavrao Tasgaonkar College of Pharmacy, India
3Department of Pharmacy, Sudhakarrao Naik Institute of Pharmacy, India
*Correspondance to: SV Tembhurne
Fulltext PDFDepression in diabetes contributes to poor metabolic control, decreased quality of life, and increased medical morbidity and mortality. Depression is believed to contribute to the development or progression of diabetic complications through its behavioral and metabolic effects. The main approach of the present study was the treatment of diabeties as well as management in the progression of depression using ethanolic extract of Murraya koenigii leaves (MKL). In the present study diabeties was induced by the intravenous administration of streptozotocin (55 mg/kg i.v.) in male Wister rat and the MKL (300 mg/kg and 500 mg/kg p.o.), standard glibenclamide (10 mg/kg p.o.) were started after 13 days of streptozotocin. While in the second study the effect of chronic treatment of MKL on progression of depression was evaluated after 9 week in streptozotocin (70 mg/kg i.v.) induced diabetic rats. The results of the first study showed that administration MKL (300 mg/kg and 500 mg/kg) for 15 days significantly (P< 0.05) decreases blood glucose level dose dependently which was comparable to standard glibenclamide. While the results of the second study showed to increased in the immobility period (P<0.05) in diabetic rat (70 mg/kg i.v.) after 9 week in streptozotocin induced diabetic animals indicates in progression of depression. While chronic treatment with MKL (500 mg/kg) up to 9 week decreases the immobility period (P<0.05) which was comparable to standard antidepressant fluoxetine (20 mg/kg p.o.). Thus the study concludes that Murraya koenigii has potent antidiabetic activity at both doses (300 mg/kg and 500 mg/kg) it decreases blood glucose level dose dependently and also has potential to decrease the progression of depression in diabeties so it could be helpful in diabetic patient for prevention of depression.
MKL; Diabeties; Muscle strength; Depression; Force swimming
SV Tembhurne, More B H, D M Sakarkar. Protective Effect of Murraya koenigii Leaves Extract in Glucose Dysregulation and Its Progression of Depression in Streptozotocin Induced Diabetic Rat. Ann Pharmacol Pharm. 2017; 2(7): 1069.