Ann Pharmacol Pharm | Volume 2, Issue 6 | Research Article | Open Access

Evaluation of Free Radical Scavenging Potential of Pyrroloquinoline Quinone (PQQ): An In Vitro Study

Narendra Kumar and Anand Kar^*

Department of Life Sciences, Devi Ahilya University, India

^*Correspondance to: Anand Kar 

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Abstract

In this investigation the free radical scavenging potential of pyrroloquinoline quinone (PQQ) was consolidated by in-vitro methods. Lipid peroxidation (LPO) was induced by ferrous sulphate (FeSO₄), hydrogen peroxide (H₂O₂) and carbon tetrachloride (CCl₄) and then the effects of five different concentrations (10, 20, 40, 80 and 160 μM) of PQQ were evaluated in liver, the major target organ of a drug. While FeSO₄, H₂O₂ and CCl₄ markedly enhanced the hepatic LPO; simultaneous administration of PQQ reduced it in a concentration dependent manner. These effects were observed in all three, FeSO₄, H₂O₂ and CCl₄ induced hepatic LPO. Out of five different concentrations of PQQ, 20 μM and 80 μM were found most effective, suggesting their beneficial /antioxidative activity. The antioxidative potential of PQQ was thus affirmed by in vitro studies also. We suggest its therapeutic use, particularly in ameliorating oxidative stress associated diseases.

Keywords:

PQQ; TBARS; CCL₄, H₂O₂; FeSo₄

Citation:

Kumar N, Kar A. Evaluation of Free Radical Scavenging Potential of Pyrroloquinoline Quinone (PQQ): An In Vitro Study. Ann Pharmacol Pharm. 2017; 2(6): 1067.