Ann Pharmacol Pharm | Volume 2, Issue 6 | Research Article | Open Access

Renoprotective Effect of Corosolic Acid in Gentamicin- Induced Nephrotoxicity and Renal Dysfunction in Experimental Rats

Sidharth Mehan*, Rajesh Dudi and Sanjeev Kalra

Department of Pharamcology, Rajendra Institute of Technology & Sciences, India

*Correspondance to: Sidharth Mehan 

Fulltext PDF

Abstract

Gentamicin is an aminoglycoside antibiotic that has a proven record of effectively treating various Gram negative bacterial infections. The selective accumulation of gentamicin in the renal proximal convoluted tubule results in the induction of nephrotoxicity. Gentamicin-induced nephrotoxicity is characterized by tubular necrosis and glomerular congestion, resulting in decreased glomerular filtration rate and renal dysfunction. In addition, induction of oxidative stress and inflammatory cascades play a key role in gentamicin nephrotoxicity. Numerous pharmacological agents have been identified to have a potential in preventing gentamicin-nephrotoxicity. However, we do not have a promising intervention clinically to blunt gentamicin-nephrotoxicity. Identification of a potent pharmacological intervention to satisfactorily halt gentamicin nephrotoxicity is imperative in clinical point-of-view. However, the effect of corosolic acid in gentamicin-nephrotoxicity is not yet known. Therefore, the present study was designed to investigate the possible effect of corosolic acid (CRA) in gentamicin-induced experimental nephrotoxicity in rats.

Keywords:

Nephrotoxicity; Reactive oxygen species; Antioxidant enzymes; Corosolic acid

Citation:

Mehan S, Dudi R, Kalra S. Renoprotective Effect of Corosolic Acid in Gentamicin-Induced Nephrotoxicity and Renal Dysfunction in Experimental Rats. Ann Pharmacol Pharm. 2017; 2(6): 1065.

Subscribe to Our Newsletter