Ann Pharmacol Pharm | Volume 2, Issue 5 | Research Article | Open Access

Resensitization of Resistant Bacteria to Antimicrobials

Mohit B Patel, Joseph W Meisel, Saeedeh Negin, Michael R Gokel, Evan Garrad and George W Gokel*

Department of Chemistry and Biochemistry, University of Missouri, USA

*Correspondance to: George W Gokel 

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Abstract

Hydraphiles are synthetic amphiphiles that form pores in bilayer membranes. A study was undertaken to determine if the formation of pores in liposomes would be reflected in the penetration of antibiotics into bacteria. The disruption of ion homeostasis by the pore-formers leads to microbial toxicity. Co-administration of hydraphiles at concentration ≤ ½ MIC and antimicrobials to E. coli or P. aeruginosa showed potency enhancements of up to 30-fold. A possible mechanism is the enhancement of antibiotic influx owing to membrane disruption and/or altering the ion balance within the bacterial cells.

Keywords:

Erythromycin; Escherichia coli; Hydraphile; Ion transport; Kanamycin; Pore formation; Pseudomonas aeruginosa; Rifampicin; Tetracycline

Citation:

Patel MB, Meisel JW, Negin S, Gokel MR, Garrad E, Gokel GW. Resensitization of Resistant Bacteria to Antimicrobials. Ann Pharmacol Pharm. 2017; 2(5): 1055.

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