Ann Pharmacol Pharm | Volume 2, Issue 4 | Research Article | Open Access

Potential Therapeutics for Dengue Virus Infection

Amrita Haikerwal1, Swatantra Kumar1, Ravi Kant1 and Shailendra K Saxena1,2*

1Department of Stem Cell/Cell Culture, King George’s Medical University (KGMU), India
2Department of Stem Cell/Cell Culture, CSIR-Centre for Cellular and Molecular Biology, India

*Correspondance to: Shailendra K Saxena 

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Abstract

Dengue is a mosquito-borne, rapidly rising viral infection with around 400 million cases per year. The toll of this high number may be attributed to the lack of availability of vaccine and specific treatment. Therefore, the development of novel antivirals is of vital importance. All the 4 serotypes of Dengue virus (DENV) could actively infect the same population with different immune responses. Thus, various studies are focused towards finding potent antiviral therapeutics to target various DENV serotypes, and further inhibit cross-reactivity among similar viruses and antibody dependent enhancement of infection. Antiviral therapeutics targeting potential restriction sites during different stages of virus life cycle were studied. Several of them were conducted using small compounds like a tetracycline derivatives, polysaccharides, lectins, or monoclonal antibodies as antiviral therapeutics for DENV infection. In this paper, we are elucidating potential antiviral therapeutics as well as immune-therapies against DENV infection.

Keywords:

DENV; Dengue fever; Immunopathogenesis; Antiviral drugs; Cytokines and Chemokines

Citation:

Haikerwal A, Kumar S, Kant R, Saxena SK. Potential Therapeutics for Dengue Virus Infection. Ann Pharmacol Pharm. 2017; 2(4): 1046.

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