Am J Clin Microbiol Antimicrob | Volume 4, Issue 1 | Research Article | Open Access

Effective Treatment and Recovery of SARS-CoV-2 Infected Infant/Children in a Family Cluster Outbreak

Zhou Chongchen1 , Luo Shuying1 , Lei Ma2 , Fiaz Ahmad3 , Zhou Yibo1 , Cheng Yibing1 and Jiao Fuyong2 *

1Henan Provincial Children’s Hospital (Children's Hospital Affiliated to Zhengzhou University), China 2 Children’s Hospital, Shaanxi Provincial People’s Hospital, Xi’an, Shaanxi, China 3 State Key Laboratory of Marine Resource Utilization in South China Sea, College of Oceanology, Hainan University, Haikou, Hainan, China

*Correspondance to: Jiao Fuyong 

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Purpose: This study aimed to diagnose coronavirus infection in children based on clinical, laboratory, imaging features and its treatment. Methods: Design: Diagnosis and treatment. Setting: Henan Provincial Children’s Hospital, Henan Zhengzhou 450018, China. Subjects: Five patients including 2 males and 3 females aging between 5 days to 8.6 years. Intervention: All patients underwent throat swabs and blood nucleic acid tests, chest radiography and Computed Thermography (CT) examinations. The patients were treated with interferon nebulization, oral Chinese medicine, ribavirin and lopinavir/ritonavir orally (1.5 ml, 2 times/d × 5d). Main outcome measure: We considered gender, age, and epidemiology and laboratory examination data. Results: Patient 1 showed reduction in hemoglobin and erythrocytes with 22 time increased dose of D2-polymer compared with other four patients. The blood cell sedimentation rate in patient 1 was 40 while in others it was normal. The C-reactive protein, calcitonin and influenza-A, B virus were normal, while SARS-CoV-2 nucleic acid by throat swab and blood tests were positive in all patients. Three of the chest radiographs showed rough lung texture, but CT case 1 showed small patchy shadows in multiple sites, cases 2 and 3 showed patchy shadows of the right lung, and cases 4 and 5 were normal. All five patients cured, discharged, and followed up were normal. Conclusion: Other than critical case, the symptomatic treatment was given with a good prognosis. Attention should be paid to avoid transmission among family members, and timely monitoring and evaluation of the pediatric status of infected families for early detection and diagnosis.


Children; Novel coronavirus; Infection; Diagnosis; SARS-CoV-2


Chongchen Z, Shuying L, Ma L, Ahmad F, Yibo Z, Yibing C, et al. Effective Treatment and Recovery of SARSCoV-2 Infected Infant/Children in a Family Cluster Outbreak. Am J Clin Microbiol Antimicrob. 2021; 4(1): 1052.

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