Aprea G, D39;Angelantonio D*, Boni A, Scattolini S, Di Sera ino G, Neri D, Sacchini L, Acciari VA, Torresi M, Centorame P, Di Giannatale E, Migliorati G, D39;Alterio N, Pomilio F
Istituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise “G. Caporale”, ItalyFulltext PDF
Phage pray and kill bacteria, are natural occurring agents, ubiquitous in nature, and could represent a global novel approach to therapy in both animals and humans. Nowadays, the problem of antimicrobial resistance, rapidly increasing in recent years, represents a major public health threat that particularly put interest in assessing the potential use of alternative antibacterial agents, including bacteriophages. Phage therapy has many advantages over traditional antibiotics such as specificity for the target organism, self-replicating activity, safety and the relative ease with which naturally occurring phages can be isolated from the environment and propagated in large numbers. The aim of this study was to evaluate the susceptibility of 12 Listeria monocytogenes (L. monocytogenes) and 3 Campylobacter jejuni (C. jejuni) strains used for initial phage isolation to bacteriophage activity and to some antibiotics frequently used in veterinary and human medicine. Moreover, we report an interesting finding related to C. jejuni 12662 strains and its apparent reversion to sensitivity to antimicrobials (ciprofloxacin, nalidixic acid and tetracycline) after been exposed to phage activity.
Aprea G, D'Angelantonio D, Boni A, Scattolini S, Di Serafino G, Neri D, et al. Activity of Bacteriophages to Control Listeria monocytogenes and Campylobacter jejuni Antibiotic Resistant Strains. Am J Clin Microbiol Antimicrob. 2018; 1(5): 1025.