Am J Clin Microbiol Antimicrob | Volume 1, Issue 5 | Review Article | Open Access

Synthesis, Characterization and Structure Activity Relationship (SAR) Studies of Differently Substituted Naphthalene and Triazine Incorporated Heterocyclic Molecule as Possible Anti-Bacterial and Anti-Fungal Agents

Rajeesh Pakkath¹, Ranjith Pakkath karuvalam¹, Koti Reddy Eeda², Ayyiliath M Sajith³ and Karickal Raman Haridas^1*

¹School of Chemical Sciences, Kannur University, Kerala, India
²Division of Chemistry, Vignan Foundation for Science, AndraPradesh, India
³Department of Pharmaceutical Sciences, College of Pharmacy, Howard University, USA

^*Correspondance to: Karickal Raman Haridas 

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Abstract

Nitrogen heterocyclic compound play an important role in medicinal chemistry due to their biological activities towards microorganisms. Differently substituted Naphthalene and Triazine incorporated heterocyclic compounds were synthesized and screened for antibacterial activity against Gram-positive and Gram-negative bacteria and anti-fungal activity. These aromatic nitrogen heterocyclic derivatives displayed remarkable in vitro antimicrobial activities against E. coli AT CC25922, S.aureus ATCC 25923, P. aeruginosa ATCC 27853, Streptococcus mutans (MTCC 890), K. pneumoniae and Bacillus subtili re-cultured bacterial strain and A. flavus, A. fumigatus, P. marneffei, T. mentagrophytes, C. Albicans.

Keywords:

Naphthalene; Triazine; Pd(dppf)2Cl2; Antibacterial activity; Antifungal activity; SAR

Citation:

Pakkath R, karuvalam RP, Eeda KR, Sajith AM, Haridas KR. Synthesis, Characterization and Structure Activity Relationship (SAR) Studies of Differently Substituted Naphthalene and Triazine Incorporated Heterocyclic Molecule as Possible Anti-Bacterial and Anti-Fungal Agents. Am J Clin Microbiol Antimicrob. 2018; 1(5): 1024.