Am J Clin Microbiol Antimicrob | Volume 1, Issue 5 | Review Article | Open Access
Supriya Pandurang Mortale and Sankunny Mohan Karuppayil*
School of Life Sciences, SRTM University, India
*Correspondance to: Karuppayil SM
Fulltext PDFC. albicans has the ability to form biofilms on biotic and abiotic surfaces. Biofilms are highly resistant to various antifungal drugs and there are complex mechanisms underlying biofilm resistance. Biofilm associated infections are urgently needed successful treatment. It has become essential to develop alternative strategies in order to overcome the limitations of current antifungal therapy against biofilm associated fungal infections. Developing new therapeutic approaches for anti-biofilm activities, there is a need to find novel drugs from natural sources. Combination therapies and exploring natural compounds and immune therapies are good approach to overcome this problem. In addition to the discovery of new antifungal drugs, vaccines, antibiotics, natural products, small molecules and synthesized compound are the important alternatives to be used alone or in combination with antifungal drugs. Combination of molecules with different drugs is an excellent strategy due to advantages of combination therapy like reduced side effects and reducing the concentration of dosages of individual drugs and reduced toxicity.
Mortale SP, Karuppayil SM. Review on Combinatorial Approach for Inhibiting Candida albicans Biofilm. Am J Clin Microbiol Antimicrob. 2018; 1(5): 1022.