Milind Davane, Basavraj Nagoba*, Asha Pichare, Pradeep Kendre
Department of Microbiology, MIMSR Medical College, Latur, IndiaFulltext PDF
Biofilm formation in Candida albicans is one of the important virulence factors causing infections refractory to antimicrobial agents. The factors responsible for increased resistance include complex architecture of biofilms, its matrix, increased efflux pumps and metabolic plasticity. Uses of various medical devices are associated with C. albicans biofilms. This review focuses on different aspects of Candida albicans biofilms. These include formation of four temporal stages, several important factors affecting biofilm formation, their resistance to commonly used antifungal agents including azoles and polyenes, the mechanism of resistance and alternative approaches inhibiting formation of biofilms (potential antibiofilm drugs). In conclusion, the detailed review of various aspects of Candida biofilms provide in depth insight of biology and pathogenesis caused by Candida biofilm. This detailed knowledge will certainly help in the better management of diseases associated with biofilm formation
Candida albicans; Biofilms; Resistance
Davane M, Nagoba B, Pichare A, Kendre P. Properties of Candida albicans Biofilms: An Update. Am J Clin Microbiol Antimicrob. 2018; 1(4): 1017.