J Clin Ophthalmol Eye Disord | Volume 4, Issue 1 | Review Article | Open Access

Pellucid Marginal Degeneration (PMD): A Systematic Review

Georgios Tsokolas*

Department of Ophthalmology, Royal Derby Hospital, University Hospitals of Derby and Burton NHS Trust, UK

*Correspondance to: Georgios Tsokolas 

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Purpose: To describe the clinical features of Pellucid Marginal Degeneration (PMD) and to give an overview of current treatment options. Materials and Methods: Literature review via PubMed, Mendeley, Scopus and Google Scholar. Results: PMD is a rare ectatic disorder of the cornea that may resemble keratoconus especially at the early stages. It mainly affects the inferior cornea and induces against the rule irregular corneal astigmatism. Acute hydrops rarely occurs. PMD patients are at risk of corneal perforation after minimal ocular trauma or even spontaneously. Management of PMD includes the use of contact lenses, spectacles and a wide range of surgical techniques with variable results. To date, there are no large prospective interventional studies to elucidate the optimum surgical approach for advanced PMD, only case reports or case series. Conclusion: Eye care practitioners need to be aware of the clinical and topographic findings of this disease, since laser refractive surgery is a contraindication. At the moment, there is no unanimity with regards to the optimum surgical treatment of PMD and larger prospective studies will be required to form a more robust algorithm for the surgical approach of PMD individuals whose vision cannot be corrected with spectacles or contact lenses.


Corneal topography; Ectasia; Keratoconus; Keratoglobus; Keratometry; Optical Coherence Tomography (OCT); Pellucid Marginal Degeneration (PMD)


Tsokolas G. Pellucid Marginal Degeneration (PMD): A Systematic Review. J Clin Ophthalmol Eye Disord. 2020; 4(1): 1031.

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