Ann Pharmacol Pharm | Volume 2, Issue 1 | Mini Review | Open Access

How and Why Do Lipid Droplets Accumulate in Gastric Epithelial Neoplasms?

Munechika Enjoji^1*, Motoyuki Kohjima², Kenji Ohe¹ and Kenshi Yao³

¹Department of Clinical Pharmacology, Fukuoka University, Japan
²Departments of Hepatology and Pancreatology, Kyushu University Hospital, Japan
³Department of Endoscopy, Fukuoka University Chikushi Hospital, Japan

^*Correspondance to: Munechika Enjoji 

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Abstract

Under the endoscopic observation with magnification endoscopy and narrow-band imaging, one of the novel findings in gastric neoplasms is white opaque substance (WOS), which is a manifestation of intracellular accumulation of lipid droplets. To elucidate the significance of this WOS formation, detailed lipid metabolism should be understood in gastric membranes. Recently, expression profiles of lipid-metabolism-associated genes in gastric tumor and non-tumor mucosa were investigated and reported. In this article, we explain the lipid accumulation and disturbance of lipid metabolism in gastric neoplasms.

Citation:

Enjoji M, Kohjima M, Ohe K, Yao K. How and Why Do Lipid Droplets Accumulate in Gastric Epithelial Neoplasms? Ann Pharmacol Pharm. 2017; 2(1): 1016.