Ahad Mir P*, Mohi-ud-din R, Akbar Dar M and Bader NG
Department of Pharmaceutical Sciences, University of Kashmir, IndiaFulltext PDF
Ethnopharmacological relevance: Arisaema propinquum Schott (Araceae) commonly known as cobra lily. Traditionally the rhizomes were used as vermifuge, in rheumatism, as stomach-ache and in snake bites. Aim: The present study was designed to evaluate the anti-arthritic potential of methanolic and aqueous extract of Arisaema propinquum Schott rhizomes in experimental animal models. Material and methods: A. propinquum Schott rhizomes were defatted with hexane and then extracted with methanol using hot extraction method in a soxhlet apparatus. Aqueous extract was prepared by decoction method. Both the extracts were evaluated at two doses 200 mg/kg and 400 mg/kg, against Freund’s complete adjuvant induced chronic immunological arthritis in rats. Paw edema, paw diameter, body weight and nociceptive threshold were measured during the study. Biochemical parameters like hemoglobin content, red and white blood cells, erythrocyte sedimentation rate, platelet count were estimated. Serum parameters like COX-2, IL6 and TNF-α were also estimated for assessing the anti-arthritic potential of methanolic and aqueous extract of A. propinquum rhizomes. Histopathological studies were also done on day 21, after animals were sacrificed. Result: Dose dependent and significant inhibition of paw edema was observed in animals treated methanolic and aqueous extract of A. propinquum. The anti-arthritic activity of extract was also supported by the results of body weight, biochemical parameters and nociceptive threshold. Treatment with the extract in experimental animals also decreased the histopathological alterations induced by Freund’s complete adjuvant in experimental animals. Conclusion: In the present study, both methanolic and aqueous extract protects synovial membrane by improving the health status through hematinic parameters and exhibits promising anti-arthritic activity. This finding thus supports the traditional claim of A. propinquum Schott rhizomes for use in rheumatism.
Arisaema propinquum; Freund’s complete adjuvant; Rheumatism; Paw edema; Biological parameters; Nociceptive threshold
Ahad Mir P, Mohi-ud-din R, Akbar Dar M, Bader NG. Evaluation of Anti-Arthritic Potential of Arisaema propinquum Schott Rhizomes against Complete Freund’s Adjuvant Induced Arthritic Rats. Ann Pharmacol Pharm. 2020;5(2):1180.