Jianshe Pan, Gungdong Chen, Ziyao Cai, Xiaodong Lin, Zifan Chen, Chuanjun Zhuo*, Deguo Jiang* and Peiwei Shan*
Wenzhou Seventh People’s Hospital, Wenzhou, ChinaFulltext PDF
Background: To systematically assess gender differences in the P300 cognitive event-related potential in normal Chinese subjects using meta-analysis.
Methods: We searched Chinese and English databases to collect studies comparing differences in P300 latency and amplitude between normal Chinese males and females. The quality of included studies was assessed according to age-matching. Standardized Mean Differences (SMDs) were calculated for differences in P300 latency and amplitude between males and females.
Results: Nine studies (417 males and 467 females) were included in the meta-analysis. Of these, five studies were assessed as high quality. The meta-analysis results revealed no statistically significant gender differences in P300 latency and amplitude. However, subgroup analysis of higher quality studies indicated that males exhibited significantly longer P300 latencies and lower amplitudes compared with females (SMD: 0.24, 95% CI: 0.08, 0.40, P=0.026; SMD: -0.32, 95% CI: -0.48, -0.15, P<0.001, respectively).
Conclusion: The results suggest the existence of significant gender differences in P300 latency and amplitude in normal Chinese subjects.
Normal Chinese subjects; P300; Gender; Meta-analysis
Pan J, Chen G, Cai Z, Lin X, Chen Z, Zhuo C, et al. A Meta-Analysis of Gender Difference in Cognitive Impairment as Indicated by the P300 ERP Component in Normal Chinese Subjects. World J Psychiatry Ment Health Res. 2019; (1): 1016.