Yvonne Valerie Yolande Mavoungou1*, Ange Clauvel Niama1, Bono Annette1, Gilbert Ndziessi1, Ghislain Pandzou1,2 and Paul-Macaire Ossou-Nguiet1,2
1Department of Public Health, University of Marien Ngouabi, Republic of the Congo 2Centre Hospitalier Universitaire, Brazzaville, Republic of the CongoFulltext PDF
Aim: Vaccination against COVID-19 on a global scale aims at limiting the spread and severe forms of the disease. Monitoring of Post-Immunization Adverse Events (PIAE) is an important activity of vaccination units. The objective of this study was to investigate the factors associated with PIAE in Brazzaville. Population and Method: This was an analytical cross-sectional study conducted in all centers attached to the Expanded Program on Immunization (EPI) in Brazzaville. All persons over 18 years of age who reported a post-vaccination reaction were selected. Results: A total of 1,010 persons reporting at least one PIAE were selected. The mean age was 46 ± 12.6 years and the predominance of males was not statistically significant; males were more affected by PIAE than females in a non-significant way (p-value =0.063). Factors associated with these PIAE were: Janssen vaccine (OR=2.7; CI = [1.4; 3.8]; p-value <0.001) for joint pain; Janssen vaccine (OR=2.03; CI = [1.3; 4.1]; p-value =0.034), the time of occurrence from 1 to 7 days after vaccination (OR=1.43; CI = [1.12; 5.01]; p-value =0.0415) and age (OR=2.01; CI = [1.91; 3.34]; p-value =0.032) for headache. Finally, for fever, the associated factors were the administration of Jansen (OR=2.4; CI = [2.01; 4.5]; p-value =0.0018) and Sputnik V (OR=1.5; CI = [1.11; 3.2]; p-value =0.041) vaccines; and the delay of occurrence from 1 to 7 days after vaccination (OR=3; CI = [2.06; 5.1]; p-value <0.001). Conclusion: Severe forms of PIAE were very uncommon. These results plead in favor of improving vaccination coverage to better protect populations against the COVID-19 pandemic.
Associated factors, PIAE, COVID-19, Brazzaville
Mavoungou YVY, Niama AC, Annette B, Ndziessi G, Pandzou G, Ossou- Nguiet P-M. Factors Associated with Adverse Events Following COVID-19 Immunization in Brazzaville. Open J Public Health. 2022;4(3):1036..