Oncol Case Rep J | Volume 6, Issue 1 | Case Report | Open Access
Karabuga B1* and Karabuga EK2
1Department of Internal Medicine, Afyonkarahisar State Hospital, Turkey
2Department of Internal Medicine, Afyonkarahisar Sinanpaşa State Hospital, Turkey
*Correspondance to: Berkan Karabuga
Fulltext PDFIntroduction: Diffuse Large B-Cell Lymphoma (DLBCL) is the most common subtype of Non- Hodgkin Lymphoma (NHL) in the world. The disease can involve many different parts of the body and is usually diagnosed with large masses in the abdomen. While the most common causes of acute pancreatitis are gallstones and alcohol, malignancies involving the pancreas are also included in the etiology. We present a rare case of DLBCL patient with bilateral multiple renal metastases presented with paraneoplastic acute pancreatitis without pancreatic involvement.
Case: A 24-year-old female patient with no known history of any disease was admitted with abdominal pain radiating to the back. The patient, who had significant amylase elevation in the tests was hospitalized with the preliminary diagnosis of acute pancreatitis. While no pathologic finding in the pancreas and biliary tract was detected in imaging studies, single mass in the left lung and bilateral multiple masses in the kidneys were detected. The patient was later diagnosed as DLBCL after further evaluation.
Discussion: In acute pancreatitis cases, the most frequently blamed causes are gallstones and use of alcohol. Anatomical malformations, various drugs and malignancies are also considered in the etiology. In our patient, no etiologic cause was found in the detailed history and imaging studies, and DLBCL was diagnosed with no pancreatic involvement, and it was thought that acute pancreatitis emerged as a paraneoplastic syndrome due to the existing malignancy. In addition, bilateral renal metastatic lesions are extremely rare in DLBCL clinic.
Conclusion: Our case report is remarkable in that it presents with the clinical presentation of paraneoplastic acute pancreatitis due to DLBCL without pancreatic involvement and bilateral multiple renal involvement, which is extremely rare in the clinic of DLBCL.
Acute pancreatitis; Diffuse large B cell lymphoma; Paraneoplastic syndrome; Metastasis
Karabuga B, Karabuga EK. Bilateral Renal Metastatic Diffuse Large B-Cell Lymphoma Presenting with Acute Pancreatitis as a Paraneoplastic Syndrome: A Case Report. Oncol Case Report J. 2023; 6(2): 1057..