Neurol Case Rep | Volume 7, Issue 1 | Case Report | Open Access

Effective Treatment with High-Dose Methotrexate for Erdheim-Chester Disease with Tumor-Like Presentation

Costa J*, Abi Najm A, Haddad A, Wakim J and Abboud H

¹Department of Neurology, Saint Joseph University, Beirut, Lebanon ²Department of Internal Medicine, Saint Joseph University, Beirut, Lebanon ³Department of Diagnostic Radiology, Saint Joseph University, Beirut, Lebanon ⁴Department of Hematology-Oncology, Saint Joseph University, Beirut, Lebanon ⁵Department of Neurology, Saint Joseph University, Beirut, Lebanon

^*Correspondance to: Jad Costa 

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Abstract

Erdheim-Chester Disease (ECD) is a non-Langerhans cell histiocytosis affecting multiple organs, particularly the central nervous system causing various manifestations such as dementia, cerebellar ataxia, headaches and seizures. Diagnosis is confirmed by a tissue biopsy. Standard treatments include interferon-alpha and several targeted therapies. We report the case of a 65-year-old woman initially presenting with an intra-axial brain lesion. Pathological examination was consistent with ECD. The patient was successfully treated with high-dose methotrexate regimen.

Keywords:

Erdheim-Chester disease; Methotrexate; Neuroimaging; Seizures

Citation:

Costa J, Abi Najm A, Haddad A, Wakim J, Abboud H. Effective Treatment with High-Dose Methotrexate for Erdheim- Chester Disease with Tumor-Like Presentation. Neurol Case Rep. 2024; 7(1):1045.