Federico Barelli-Corbo1a, Benedetta Acciavatti1a, Adriana Amalfitano2, Alessandro Arcovito2, Cinzia Callà2, Massimo Cordaro1 and Giuseppina Nocca2,3*
1Institute of Dentistry, Università Cattolica del Sacro Cuore, Largo Francesco Vito - 00168 Rome, Italy
2Institute of Biochemistry and Clinical Biochemistry, Università Cattolica del Sacro Cuore, Largo Francesco Vito - 00168 Rome, Italy
3Istituto di Chimica del Riconoscimento Molecolare, CNR, Largo Francesco Vito - 00168 Rome, Italy a These authors contributed equally to this work
Several studies have already demonstrated that the incomplete polymerization of resin-based dental materials causes the release of monomers, which might interact with pulp cells (both fibroblasts and stem cells). Due to possible applications of these cells in regenerative dentistry, the aim of this study was the evaluation in vitro cell differentiation after the exposition to sub-cytotoxic concentrations of triethylene glycol dimethacrylate (TEGDMA) and 2-hydroxyethyl methacrylate (HEMA) for 24 h. Our preliminary results seem indicate that HEMA and TEGDMA did not alter the normal differentiation and mineralization process of pulp cells. On the contrary, when dental pulp stem cells were treated with the same monomer concentrations these capabilities were lost. Thus, the use of pulp cells derived from teeth treated with composite resins from applications in regenerative dentistry may be considered.
Barelli-Corbo F, Acciavatti B, Amalfitano A, Arcovito A, Callà C, Cordaro M, et al.Effects of Two Methacrylic Monomers on Pulp Cells Differentiation Capability: A Preliminary In Vitro Study. Mater Sci Eng J. 2017;1(1):1003.