J Res Notes | Volume 1, Issue 1 | Research Article | Open Access

Identification of Conserved Residues on the Interaction Interface of VEGF with Urological Cancer-Related Proteins by a Systems Biology Approach

Kleber Santiago Freitas e Silva^*, Raisa Melo Lima, Lívia do Carmo Silva, Juliana Santana de Curcio, Thaynara Gonzaga Santos and Isabele Pereira Tannous

Biological Sciences Institute, Federal University of Goias, Brazil

^*Correspondance to: Kleber Santiago Freitas e Silva 

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Abstract

Cancer is a costly and complex public health problem worldwide and urological cancer is responsible for more than 19% of all the types of cancer. The most common urinary cancers affect the prostate, bladder and the kidneys. Tumorous cells rely on oxygen and nutrients availability and the elimination of metabolic products mediated by angiogenesis. Several genes and proteins are related to angiogenesis. VEGF is one of the major proteins that regulate angiogenesis processes and several other genes regulate VEGF. The proteins MDM2, CRYAB and BRAC1 expression interacts with VEGF and dysregulation of such interactions, perhaps through the presence of genetic variation, may bring a higher susceptibility to cancers. Polymorphisms within the coding sequence of those genes might alter expression, protein structure and PPI patterns and consequently diseases. Here, we have shown a systems biology approach for interaction between VEGF and the urological cancer-related proteins MDM2, CRYAB and BRCA1 through the identification of hot spots within the interface of interaction of VEGF and target proteins. Several SNPs identified in clinical practice and deposited on dbSNP were related to the predicted hot spots in the present research. Further analyses should be performed and through the hot spots presented here, the proteins under study could be used as molecular markers and peptide PPI modulators could be design and tested as alternative therapies against urological cancers.

Keywords:

VEGF; MDM2; CRYAB; BRCA1; Systems biology; Hot spots

Citation:

Freitas e Silva KS, Lima RM, do Carmo Silva L, de Curcio JS, Santos TG, Tannous IP. Identification of Conserved Residues on the Interaction Interface of VEGF with Urological CancerRelated Proteins by a Systems Biology Approach. J Res Notes. 2018;1(1):1005.