J Res Notes | Volume 1, Issue 1 | Research Article | Open Access
Alberto Rodriguez-Archilla* and M Tiscar Garcia-Gamez
Faculty of Dentistry, University of Granada, Spain
*Correspondance to: Alberto Rodriguez-Archilla
Fulltext PDFBackground: Oral leukoplakia is a frequent potentially malignant disorder of the oral mucosa. Its main etiological factors are tobacco and/or alcohol consumption and it is a lesion that may suffer malignant transformation.
Objective: To assess the possible risk factors related to oral leukoplakia. Search
Methods: A PubMed search through February 2018, using the following keywords was performed: “leukoplakia, oral” and “risk factors”. Selection Criteria: Studies with findings on risk factors for oral leukoplakia. Data Analysis: The data were analyzed using statistical software RevMan 5.3 (The Cochrane Collaboration, Oxford, UK). For continuous outcomes, the estimates of effects of an intervention were expressed as Mean Difference (MD) using the Inverse Variance (IV) method and, for dichotomous outcomes; the estimates of effects of an intervention were expressed as Odds Ratios (OR) using Haenszel Mantel (HM) method, both with 95% confidence intervals.
Results: 14 studies on risk factors of OL were included in this meta-analysis. Main risk factors for OL were: high-risk HPV infection (OR: 6.03), any HPV infection (OR: 5.41), tobacco consumption (OR: 3.84), male gender (OR: 1.84) and age over 55 years-old (OR: 1.73). Conclusions: HPV infection and tobacco consumption were the most important risk factors for oral leukoplakia.
Oral leukoplakia; Precancerous conditions; Risk factors
Rodriguez-Archilla A, Garcia-Gamez MT. Risk Factors for Oral Leukoplakia: A Meta-Analysis. J Res Notes. 2018;1(1):1001.