J Res Notes | Volume 4, Issue 1 | Research Article | Open Access

Elevated Plasma Homocysteine Level in Chronic Heart Failure is an Important Predictive Factor for Cardiovascular Mortality in Males with Coronary Artery Disease

Kozdag G^1*, Emre E², Tokatli A³, Celikyurt U¹, Kahraman G¹, Sahin T¹, Daglioz Gorur G⁴, Ural D¹ and Agir AA¹

¹Department of Cardiology, Medical School of Kocaeli University, Turkey ²Sakarya Training and Research Hospital, Turkey ³Golcuk Necati Celik Government Hospital, Turkey 4Department of Nuclear Medicine, Medical School of Kocaeli University, Turkey

^*Correspondance to: Kozdag G 

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Abstract

Previous reports have consistently showed that high Homocysteine (Hcy) levels were associated with high risk for cardiovascular disease. Furthermore, there is emerging epidemiological evidence that Hyperhomocysteinemia (HHcy) has been reported as an independent risk factor for fatal and non-fatal cardiovascular disease. Increased Hcy levels have been identified as a crucial clinical issue in Chronic Heart Failure (CHF) which is probably one of the most important areas of interest for HHcy. The aim of this study was to determine the prognostic importance of Hcy levels in female and male patients with CHF as well as relationship between Coronary Artery Disease (CAD) and Hcy levels in males and females in CHF. A total of 602 patients were included into the study in retrospective cohort design. The median follow-up duration was 38 ± 15 months. The mean age of the cohort was 63 ± 13 years with mean ejection fraction of 26 ± 10%. There were 233 cardiac deaths among the study population which means an overall cardiac mortality rate of 38.7%. It was demonstrated that the male patients with CAD who had higher Hcy levels died more than male patients with CAD whose Hcy levels were lower (20.2 ± 8.6 μmol/L vs. 17.8 ± 8.2 μmol/L, p=0.02). The female patients who had CAD had no statistical difference between survivors and non-survivors in terms of Hcy. Patients without CAD there was no statistical difference between survivors or non-survivors in terms of Hcy levels in both genders. Our study showed that serum Hcy levels were significantly elevated in male non-survivors compared to male survivors who had CAD with severe systolic dysfunction while the difference did not reach statistical significance between female groups.

Citation:

Kozdag G, Emre E, Tokatli A, Celikyurt U, Kahraman G, Sahin T, et al. Elevated Plasma Homocysteine Level in Chronic Heart Failure is an Important Predictive Factor for Cardiovascular Mortality in Males with Coronary Artery Disease. J Res Notes. 2021; 4(1): 1023..