J Neurol Neurosurg Spine | Volume 5, Issue 1 | Research Article | Open Access
Ranaiy MS, Balderlou FB, Farokhi F*
Department of Biology, Urmia University, Urmia, Iran
*Correspondance to: Farah FarokhiFulltext PDF
Background: Simvastatin is a lipophilic statin and can cross the blood-brain barrier. This study aimed to investigate simvastatin's effect on the brain weight ratio to body weight in male rats. Method: For the experiment, 36 Wistar male rats with an average weight of 250 g to 300 g were divided into six groups (each group comprised six heads). Group (1) Control group, (2) Vitamin D dose 5 μg/kg, (3) Simvastatin group dose 1 mg/kg, (4) Simvastatin group dose 10 mg/kg, (5) Simvastatin group dose 1 mg/kg + vitamin D dose 5 μg/kg, (6) Simvastatin group dose 10 mg/kg + vitamin D dose 5 μg/kg. The duration of drug use was 28 days. After the end of the treatment period, the animals were weighed, and their brain tissue was completely removed after euthanasia. Then their brains were weighed. The data were analyzed using SPSS19 software. P<0.05 was considered a significant level. Examining the ratio of brain weight to body weight showed that simvastatin in doses of 1 mg and 10 mg does not significantly affect the ratio of brain weight to body weight of rats. Discuss: Lipophilic statins such as simvastatin have great effects on the nervous system, and brain cholesterol synthesis is significantly affected by treatment with high doses of simvastatin. Conclusion: Simvastatin drug, neither in low dose nor in high dose, has any effect on the ratio of brain weight to body weight of rats.
Body weight; Brain weight; Male rat; Simvastatin; Vitamin D
Ranaiy MS, Balderlou FB, Farokhi F. Simvastatin does not Affect the Brain Weight and Body Weight of Rats. J Clin Neurol Neurosurg Spine. 2022; 5(1): 1022..