J Heart Stroke | Volume 2, Issue 2 | Research Article | Open Access
Valdeviño JO1, Bellincanta GA1, Soares MCP1, Lara LM2, Coelho GMM2 and Sampaio MF2*
1Department of Cardiology, São Camilo University, Brazil
2Department of Cardiology, Dante Pazzanese Institute of Cardiology, Brazil
*Correspondance to: Marcelo Ferraz Sampaio
Fulltext PDFIntroduction: Vascular calcification (VC) is a physiopathological process of utmost importance at the clinic nowadays, being a cardiovascular risk factor and closely correlated with chronic kidney disease (CKD).
Objective: To describe the physiopathology of the vascular calcification involved in CKD, to expose the risk factors and disorders related to it and to correlate the function of the biomolecular markers involved in this process.
Methodology: Search publications indexed in the Lilacs, Scielo and Medline’s databases (by PubMed), using Boolean operators ‘and’ and 'or’. Works selected from the last fifteen years in English, Spanish and Portuguese, involving adults, regardless the gender. Works regarding the treatment of the pathologies were excluded.
Results: A total of 567 scientific articles were found, whose summaries were appraised. After application of exclusion criteria, 74 articles were used to base introduction and discussion, and 18 of them referred specifically to markers related to VC and CKD. There were several markers and genetic loci identified, registered and correlated, as inducers or inhibitors of VC, in a clinical condition.
Conclusion: The several studies refer to specific markers separately, not establishing clear relation among them. Although some address the genetic subject of the process, they are limited to specific polymorphisms. The physiopathology of VC still presents several gaps; it is necessary new studies in order to correlate inducers and inhibitors of the process, as well as to explore its clinical application.
Vascular calcification; Chronic renal disease; Chronic renal failure; Kidney failure
Valdeviño JO, Bellincanta GA, Soares MCP, Lara LM, Coelho GMM, Sampaio MF. Vascular Calcification in Chronic Kidney Disease: An Updated Physiopathology Approach. J Heart Stroke. 2017; 2(2): 1021.