J Gynecol Oncol | Volume 6, Issue 1 | Research Article | Open Access
Zhao Y1,2,3#, Cheng S1,2#, Yang Y4, Li Z4* and Wang Y1,2*
1Department of Gynecology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, China
2Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai First Maternity and Infant Hospital, School of Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Tongji University, China
3Department of Obstetrics and Gynecology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, China
4Department of Clinical Research Unit, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, China
#These authors contributed equally to this work
Background: Growing evidence supports that Lactic Dehydrogenase (LDH) and Albumin (ALB) are associated with the development of Epithelial Ovarian Cancer (EOC). Our study was the first to validate the prognostic value of LDH to Albumin Ratio (LAR) in patients with epithelial ovarian cancer. Patients and Methods: A total of 259 EOC patients were included in this retrospective study. Patients were stratified into three groups according to the tertile results for LAR. Multivariate Cox regression was used to explore the impact of LAR on predicting the prognosis of EOC patients, including patients stratified by CA125 level, residual tumor and FIGO stage. The survival curves were created using the Kaplan-Meier method and differences in survival time between LAR levels were evaluated using the Log-rank test. Results: Compared with patients with the lower LAR, patients with the higher LAR were older, (p<0.014), more likely to have a disease status with bilateral ovarian lesions (p<0.003), lymph node metastasis (p<0.03), advanced FIGO stage (p<0.001) and higher CA125 levels (p<0.001). Multivariate regression analyzes found that T3 (LAR T3 compared with LAR T1, HR=2.461; 95% CI=1.176-5.155; P=0.017) was associated with poor prognosis of EOC patients. Further subgroup multivariate cox analysis showed that LAR was negatively associated with overall survival time especially in EOC patients with CA125 ≤ 600 U/ml (p=0.007). Kaplan-Meier methods also indicated that higher LAR was significantly related to poor OS (p<0.001). Conclusion: LAR was associated with overall survival time in EOC patients, among patients with CA125 ≤ 600 IU/ml in particular. As an intervenable biomarker, LAR provided a new insight for risk classification and personalized treatment to improve the prognosis of EOC patients.
Ovarian cancer; Lactate dehydrogenase; Albumin; Prognosis
Zhao Y, Cheng S, Yang Y, Li Z, Wang Y. Preoperative Lactate Dehydrogenase to Albumin Ratio (LAR) as a Prognostic Factor of Epithelial Ovarian Cancer. J Gynecol Oncol. 2024;6(1):1079..