J Gastroenterol Hepatol Endosc | Volume 2, Issue 3 | Review Article | Open Access
Walter Coyle1 and Paul J Pockros1,2*
1Division of Gastroenterology/Hepatology, Scripps Clinic, USA
2Scripps Translational Science Institute, both in La Jolla, USA
*Correspondance to: Paul J Pockros
Fulltext PDFThis update summarizes key 2016 publications in gastroenterology and hepatology that the authors believe are of particular relevance to general internists. We reviewed 20 general medicine, gastroenterology, and hepatology journals to identify articles with broad clinical importance or novel findings. This year's liver related topics include a new drug for patients with primary biliary cholangitis who have an inadequate response to ursodiol, the loss of HBsAg with the combination of tenofovir disoproxil fumarate (TDF) and peginterferon alpha-2a (PEG2a) in patients with chronic hepatitis B (HBV), the use of an agonist of the peroxisome proliferator-activated receptoralpha and –delta in patients with nonalcoholic steatohepatitis (NASH), and lastly the benefit of terlipressin plus albumin in patients with cirrhosis and hepatorenal syndrome type 1. Diseases of the upper gastroenterology tract include a new randomized, controlled trial looking at three different regimens for treatment of Helicobacter pylori infection and a large, national study looking at the risk of small bowel enteropathy with the angiotensin receptor blocker olmesartan. We also address the issue of proton pump inhibitor use with recent associations noted with coronary artery, kidney disease and dementia. For colonic disease we will review the recent US Preventive Services Task Force (USPSTF) update on colon cancer screening and discuss stool based screening tests for colon cancer and stool tests for triaging patients who present with bowel symptoms. We will address the use of diet therapy in irritable bowel syndrome with a prospective, randomized diet trial. The last article of interest will review the literature on the increasingly frequent cannabinoid hyperemesis syndrome and stress the importance of diagnosing this entity.
Coyle W, Pockros PJ. Update in Gastroenterology and Hepatology: Evidence Published in 2016. J Gastroenterol Hepatol Endosc. 2017;2(3):1015.