Mohamed AA Bassiony*, Amr T El Hawary and Marwan N Elgohary
Department of Internal Medicine, Gastroenterology & Hepatology Unit, Zagazig Faculty of Medicine, EgyptFulltext PDF
Background: Helicobacter pylori(H. pylori), a highly prevalent gastrointestinal organism, infects more than 50% of the global population. It is the most common risk factor for peptic ulcer disease, cancer stomach & gastric lymphoma. Eradication therapy regimens for H. pylori are highly effective. However, bacterial resistance to antibiotics & patients non-adherence to the treatment regimens significantly increased the recurrence rates of H. pylori infection in the last few decades. Study Aim: To assess the prevalence & possible risk factors of H. pylori recurrence in Egyptian patients after eradication therapy. Patients and Methods: We evaluated & followed up 157 patients for one year after confirmed successful eradication of H. pylori infection. We investigated the patients at 3, 6, 9 & 12 months for recurrence of H. pyloriinfection using urea breathe & stool antigen tests. Results and Conclusion:We found a one-year recurrence rate of 19% after successful eradication therapy of H. pylori. The education level of the patients & alcohol consumption were the most significant predictors of H. pylori recurrence. The one-year recurrence rate in our study is high but comparable to those reported in the developing countries most probably due to high rates of reinfection & non-adherence to the preventive measures.
H. pylori; Proton pump inhibitors; Eradication therapy; Bacteria resistance; Recurrence
Bassiony MAA, El Hawary AT, Elgohary MN. Recurrence of Helicobacter pylori Infection after Successful Eradication Therapy in Egyptian Patients. J Gastroenterol Hepatol Endosc. 2020;5(3):1085..