J Dermatol Plast Surg | Volume 2, Issue 1 | Review Article | Open Access
Armando Rosique Costa Aguiar1*, Cesar Isaac2, Andre Oliveira Paggiaro3 and Elisabeth Mie Hosaka4
1Department of Plastic Surgery, FMUSP, Brazil
2Department of Physician, FMUSP, Brazil
3Department of Physician Responsible for the Tissue Bank, FMUSP, Brazil
4Nurse Member of the Research Laboratory on Cell Culture and Wounds, FMUSP, Brazil
*Correspondance to: Armando Rosique Costa Aguiar
Fulltext PDFThe disease diabetes depictures a heterogeneous group of metabolic disorders that arise as a result of hyperglycemia due to the deficit of secretion and/or insulin action. How it promotes systemic alterations, short and long-term complications have high impact for de health system of countries. Among its long-term complications, foot ulcer is the one that generates more hospital admissions. These wounds often become chronic due to a series of molecular and cellular aberrations of the healing process, being the main mechanisms the following: high concentrations of matrix metalloproteinases (MMPs), neuropathy, high probability of infection and non-physiological inflammatory response, oxidative stress, excessive formation of AGEs (advanced glycoxidation end-products), deficient neoangiogenesis, imbalance between metabolism and nutrient delivery, inadequate concentrations of growth factors and gene expression regulators, and cellular abnormalities. With better scientific understanding of these events and physiological healing, new approaches to disease can provide more satisfactory results to the treatment.
Diabetic foot; Wound healing; Wounds and injuries; Diabetes mellitus; Advanced glycosylation end-products
Aguiar ARC, Isaac C, Paggiaro AO, Hosaka EM. Lower Limb Ulcers in Diabetic Patients: Molecular and Cellular Mechanisms. J Dermatol Plast Surg. 2017; 2(1): 1012.