J Dermatol Plast Surg | Volume 2, Issue 1 | Review Article | Open Access
Afton Chavez*, Joseph M Rosen and Hilton Kaplan
Department of Dermatology, Dartmouth-Hitchcock Medical Center, USA
*Correspondance to: Afton Chavez
Fulltext PDFNon-healing wounds, burns, and scars from surgical incisions and trauma cost approximately 70 billion dollars annually in the US alone. A number of interventions have been attempted throughout history to facilitate wound healing and skin repair, yet despite these treatments, the healthcare costs and quality of life implications that arise from non-healing wounds, scarring, and skin aging continue to challenge individual patients as well as the healthcare economy. This article describes novel and emerging scientific breakthroughs and technologies to promote healthy wound healing and skin repair using regenerative medicine, the future of scarless wound healing. Topics include: percutaneous wound healing (PCI) to evoke natural cellular regenerative processes, novel transcutaneous drug and molecular delivery systems to apply targeted therapies, new techniques for stem cell identification, isolation, and replication to select for well-functioning and specific cells, and innovative scaffolding to lay the selected cells onto to foster the optimum growth environment and promote scarless healing. In addition, this review will provide an overview of historical attempts at facilitating wound healing, describe the current understanding of the normal and abnormal wound healing process, and discuss existing paradigms for treating abnormal wound healing and skin repair.
Chavez A, Rosen JM, Kaplan H. A Revolution in Dermatology and Plastic Surgery - Moving to Scarless Healing Through the Application of Regenerative Medicine. J Dermatol Plast Surg. 2017; 2(1): 1008.