J Dent Oral Biol | Volume 9, Issue 1 | Research Article | Open Access

Immunohistochemical Markers in Head and Neck Rhabdomyosarcoma of Pediatric Population – A Systematic Review

Sai Sudha M¹, Subhashini P¹, Senthil Kumar A², Karthik S^3*, Barun Kumar⁴ and Karthi Kumar M⁵

¹Department of Pathology, Sree Balaji Medical College and Hospital, Chennai, India
²Department of Oral & Maxillofacial Surgery, Tamilnadu Govt Dental College Hospital, India
³Department of Dentistry/Oral and Maxillofacial Pathology, PSP Medical College Hospital and Research Institute,
India
⁴Oral and Maxillofacial Surgery, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, India
⁵University of Science and Technology in Fujairah, UAE

^*Correspondance to: Karthik Shunmugavelu 

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Abstract

Background: Mesenchymal cell origin tumor with malignant nature, rhabdomyosarcoma, a sarcoma of solid tumor type in pediatric population, presents different varied muscle cells architecture in the oral and maxillofacial region. Immunohistochemistry plays a pivotal role in the differentiation of rhabdomyosarcoma from other soft tissue tumors of pediatric population. Material and Methods: Major databases such as Medline were explored detailed literature search in resulting in a systematic review pertaining to immunohistochemistry of rhabdomyosarcoma especially in the oral and maxillofacial region of pediatric population, leading to determination of anatomy, classification, histopathology, age, gender and immunohistochemical markers. Results: Seven original research scientific articles pertaining to the head and neck pediatric rhabdomyosarcoma were highlighted depicting heterogenous cellular features, which is to be confirmed by immunohistochemistry. Conclusion: Histopathology plays an important role in the diagnosis of pediatric head and neck rhabdomyosarcoma whereas immunohistochemistry is the main differentiation factor in case of subtypes, nature, management and prognosis.

Keywords:

Pediatric; Rhabdomyosarcoma; Head; Neck; Oral; Maxillofacial; Pathology; Immunohistochemistry

Citation:

Sai Sudha M, Subhashini P, Senthil Kumar A, Karthik S, Barun Kumar, Karthi Kumar M. Immunohistochemical Markers in Head and Neck Rhabdomyosarcoma of Pediatric Population – A Systematic Review. J Dent Oral Biol. 2024; 9(1): 1224. ISSN: 2475-5680.