Department of Pediatric Dentistry, School and Hospital of Stomatology, Peking University, ChinaFulltext PDF
During the treatment of endodontic diseases, multipotential dental stem cells will experience a certain degree of nutritional deficiency, such as hypoxia or ischemia, in the process of reconstructing the root canal microenvironment. It is becoming a hot area of research that how to deal with the cells to survive the harsh living environment, retaining or even improving their biological activity. This review summarized the literatures concerning the cellular adaptative responses and mechanisms to hypoxia after specific beforehand treatment, proposing that rapid extreme hypoxia precondition could activate a series of self-protective responses of cells, such as Hypoxia-Inducible Factor (HIF) pathway activation, mitochondrial Reactive Oxygen Species (ROS) production and Unfolded Protein Response (UPR). This review raised a promising pretreatment that could enhance the protective efficacy of existing vital pulp therapies.
Hypoxia-Inducible Factor;Unfolded Protein Response;mitochondrial Reactive Oxygen Species
Zhu N. Specific Hypoxic Preconditioning Could Improve the Activity and Adaptability of Cells in Nutritionally Deficient Environment. J Dent Oral Biol. 2022; 7(4): 1201. ISSN: 2475-5680.