J Dent Oral Biol | Volume 3, Issue 1 | Research Article | Open Access

Evaluation of Cytotoxicity of Polyetheretherketone (PEEK) as a Dental Implant Material

Roseline Meshramkar*, Rhea Mahajan, Lekha KP and Ramesh Nadiger

Department of Prosthodontics, SDM College of Dental Sciences and Hospital, India

*Correspondance to: Roseline Meshramkar 

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Purpose: PEEK (polyetheretherketone) is a synthetic polymer being used increasingly as a dental implant material due to its iso-elastic nature and enhanced mechanical properties. This study analysed the cytotoxicity and biocompatibility of PEEK which helps to improve its bioactivity and ensure widened clinical prospects in future .
Methods: Samples of PEEK dental implant material were added to murine T3T fibroblasts which were cultured in Dulbecco’s modified eagle medium at 37ºc. After 24 hours incubation at 37ºc and 5% carbon dioxide, the medium was replaced with 200 micro litre of medium which contained extracts of PEEK implant material. Cell morphology was analysed using Motic Inverted Microscope. Results: The result for biocompatibility of PEEK as a dental implant material when evaluated using Colony-forming unit fibroblast assay, was positive showing no signs of cytotoxicity. Conclusion: With analogous physical and mechanical properties to bone, PEEK has proved to be a potent biocompatible dental implant material.




Meshramkar R, Mahajan R, Lekha KP, Nadiger R. Evaluation of Cytotoxicity of Polyetheretherketone (PEEK) as a Dental Implant Material. J Dent Oral Biol. 2018; 3(2): 1127.

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