David Hinkl1, Jacob Krischer1, Callie Mincy1, Lurdes Queimado2 and Asha Eapen3*
1School of Dental Medicine and Department of Biological Sciences, Southern Illinois University, USA
2Department of Otorhinolaryngology, The University of Oklahoma Health Sciences Center, USA
3College of Dentistry, University of Illinois at Chicago, USA
Salivary gland cancers, neoplasms of the head and neck, have shown to exhibit a wide variety of biological, pathologic, and clinical variations. The standard treatment protocol approach is surgical resection of the gland or the tumor followed with postoperative radiation. Currently, studies have been focused on identifying, characterizing and exploring molecular signatures at the genomics and protein levels which could be used for potential therapies and clinical trials. Fra-1, a member of the activator protein-1 transcription factor superfamily, has shown to play pivotal roles in various types of malignancies. To date, no research has been performed in identifying the role of Fra-1 in salivary gland cancers. In this study, we first demonstrated that Fra-1 is highly expressed in salivary gland cancers. Secondly, data obtained from immunoblot analysis also showed Fra-1 protein expression to be highly expressed in the tumor cell lines and in the tumor matrix induced cells when compared to the immortalized normal salivary gland cells. Furthermore, our results showed nuclear localization of Fra-1 protein in the tumor cell lines and the tumor matrix induced transformed cells. Examining the role of Fra-1, would shed light in providing a therapeutic approach of salivary gland cancers.
Hinkl D, Krischer J, Mincy C, Queimado L, Eapen A. Fra-1 Expression in Salivary Gland Cancer Cells. J Dent Oral Biol. 2016; 1(4): 1018.