J Dent Oral Biol | Volume 9, Issue 2 | Review Article | Open Access
Gunawan E, Ikrima A, Rohmah DK and Bachtiar EW*
Department of Oral Biology, Universitas Indonesia, Jakarta, Indonesia
*Correspondance to: Endang Winiati Bachtiar
Fulltext PDFBackground: Oral microorganisms have an important role, especially in maintaining physiological balance, such as bacterial communities and host cell immunity in the oral mucosal epithelium and saliva. If there is a disturbance in homeostasis, it can cause certain diseases such as periodontal disease. Periodontal disease is generally caused by certain bacteria such as Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia. Content: Tannerella forsythia is one of a group of red complex anaerobic bacteria that can mediate and bind to a number of other bacteria. In addition, Tannerella forsythia Lipopolysaccharide (LPS) is one of the virulence factors and also an inflammatory factor that plays a role in inducing cytokines such as Interleukin (IL)-1β, (IL)-6, and (IL)-8 so that it can aggravate the development of periodontitis. The progression of periodontitis can be controlled by proinflammatory cytokines and antimicrobial peptide secretion which is modulated by vitamin D in the oral cavity. Vitamin D has two mechanisms in suppressing periodontitis, namely first as an anti-microbial by inducing the production of β-defensins and cathelicidin which have strong antimicrobial activity, one of which is against Tannerella forsythia bacteria. Then the second as anti-inflammatory which occurs through decreased production of cytokines Interleukin (IL)-6 and Tumor Necrosis Factor (TNF)-α which are inflammatory factors of Tannerella forsythia. Summary: Therefore, it can be concluded that vitamin D has a close relationship with the oral ecosystem as well as the cytokine expression and bacterial profile of Tannerella forsythia.
Cytokine Expression; Tannerella forsythia; Vitamin D
Gunawan E, Ikrima A, Rohmah DK, Bachtiar EW. Identification of Vitamin D Potential, Oral Cavity Ecosystem and Its Relationship with Cytokine Expression and Bacterial Profile of Tannerella forsythia. J Dent Oral Biol. 2024; 9(2): 1231.