J Clin Obstet Gynecol Infertil | Volume 7, Issue 2 | Research Article | Open Access

Use of Letrozole in Ovarian Stimulation in In Vitro Fertilization

Pierro Saraiva ML1 , Samama M1,2, de Arruda Veiga EC1,3*, Ikeda F1 , Rita de Cassio de CPP1 , Jarmy-Di Bella S2 and Ueno J

1 GERA Institute for Teaching and Research in Reproductive Medicine of São Paulo, GERA, Brazil
2 Department of Gynecology, Paulista School of Medicine, Federal University of São Paulo, Brazil
3 Department of Obstetrics and Gynecology, The Clinical Hospital, University of São Paulo, Brazil

*Correspondance to: de Arruda Veiga EC 

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Background: Letrozole is a medication that alone or combined with clomiphene citrate has been used for ovarian stimulation in women undergoing IVF. The objective of this narrative review is to investigate in the recent literature what are the main findings related to the use of letrozole in ovarian induction in human reproduction.
Methods: The search strategy was to use the keywords letrozole and ovarian stimulation and In Vitro fertilization in the PubMed database in the last five years in free text articles. Results - 62 articles were found that applying the eligibility criteria were selected for this narrative review 12 articles.
Results: The main findings of this study which has information about author, year, country, study design, number of participants and more findings of each of the papers selected for this narrative review. Conclusion: Although letrozole is a low-cost and safe medication for women, widely used in ovarian stimulation with benefits in endometrial receptivity, clinical results such as pregnancy rate and number of live births still need large randomized trial studies.


Keywords: Letrozole; Gonadotropins; Ovarian stimulation; In vitro fertilization; Assisted reproductive


Eduardo Carvalho de Arruda Veiga, GERA Institute for Teaching and Research in Reproductive Medicine of São Paulo, Rua Peixoto Gomide Número 515 1 Andar – CEP: 01409- 001, São Paulo, Brazil.

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