J Clin Obstet Gynecol Infertil | Volume 4, Issue 1 | Research Article | Open Access

Dehydroepiandrosterone (DHEA) Combining Metformin - Adjuvant Agents for Ovulation Induction in Poor Ovarian Responders

Chih-Chia Chang^1*, Yu-Jui Chang² and Yu-Hsuan Chang³

1Department of Gynecology, Reproductive Medical Center, Mei Tsun OB/GYN Clinic, Taichung, Taiwan 2Chang Hua Christian Hospital, Taiwan 3Taiwan University Hospital, Taiwan

^*Correspondance to: Chih-Chia Chang 

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Abstract

Objective: To investigate the impact of Dehydroepiandrosterone (DHEA) combining Metformin on IVF-ET outcomes in Poor Ovarian Responders (PORs). Materials and Methods: This is a retrospective cohort study. There were 237 women undergoing IVF-ET cycles. A total of 106 cycles met the Bologna criteria (44.8%) as poor responders in this study period. They were divided into two groups according to with or without supplementation. Results: The number of oocytes retrieved (3.5 ± 2.5 vs. 1.5 ± 0.8, p=0.027), the clinical pregnancy rate (21.7 vs. 11.5, p=0.008) and the live birth rate (16.7 vs. 8.7, p=0.007) were significantly higher in the group with supplementation than in the group without. Conclusion: The adjuvant agents: DHEA and Metformin for ovulation induction seemed to improve the number of oocytes retrieved, clinical pregnancy rate and live birth rates in poor ovarian responders.

Keywords:

Adjuvant agents; Controlled ovarian hyperstimulation; Dehydroepiandrosterone; Metformin; Ovulation induction; Poor ovarian responders

Citation:

Chang C-C, Chang Y-J, Chang Y-H. Dehydroepiandrosterone (DHEA) Combining Metformin - Adjuvant Agents for Ovulation Induction in Poor Ovarian Responders. J Clin Obstet Gynecol Infertil. 2020; 4(1): 1046..