J Clin Nephrol Kidney Dis | Volume 2, Issue 1 | Research Article | Open Access
Tam MJC, Cabanayan-Casasola CB and Danguilan RA*
Department of Adult Nephrology, National Kidney and Transplant Institute, East Avenue, Quezon City, Philippines
*Correspondance to: Danguilan RA
Fulltext PDFBackground: The number of patients with ESRD is increasing and the gap between the demand for KT and available donors is widening. Thus deceased donation is very important to the donor pool for ESRD.
Objectives: This study aims to determine the long term graft and recipient outcome of deceased donor renal transplantation at the National Kidney and Transplant Institute from 2002-2007 and to determine the donor and recipient factors that affect graft and recipient survival.
Materials and Methods: This is a retrospective cohort of deceased donor KT from January 2002 to December 2007. Data were reviewed and collected from National Kidney and Transplant Institute medical records and the Philippine Renal Disease Registry (PRDR). Recipient and donor demographic profile were expressed as frequency counts, percentages and means with standard deviation. Kaplan Meier was used to determine graft and patient survival and logistic regression to establish correlation between certain factors and survival.
Results: Among 1,598 KT, 1,488 were from living donors and 110 from deceased donors. In the study, 91 patients were included. The mean recipient age was 40.40 ± 11.8 years and 65.9% were males. The primary renal diseases were chronic glomerulonephritis (63.7%), diabetic nephropathy (18.7%) and hypertensive nephrosclerosis (6.6%). Around 39.6% had 3 HLA mismatches and 61.5% had at least 1 DR match. Majority received induction therapy (90.1%) and 64.8% had tacrolimus based immunosuppressive regimen. The patient survival rate at 1st, 3rd, 5th and 7th years was 91%, 89%, 86% and 86% while graft survival was 89%, 79%, 73% and 68% respectively. Infection was the leading cause of death. Cold ischemia time was significantly associated with patient survival (P=0.033) while patients with male donors had significantly better graft survival (P=0.001).
Conclusion: There was an acceptable outcome of KT from deceased donors up to 7 years post KT.
Cadaveric donor kidney transplantation; Graft survival; Patient survival
Tam MJC, Cabanayan-Casasola CB, Danguilan RA. Long Term Graft and Recipient Outcome of Deceased Donor Renal Transplantation at the National Kidney and Transplant Institute. J Clin Nephrol Kidney Dis. 2017; 2(1): 1009.